stress fibers การใช้

• RhoA regulates the actin cytoskeleton and forms stress fibers and focal adhesions.
• This protein localizes to focal adhesion sites and along actin stress fibers.
• The protein localizes to the cytosol in regions lacking actin stress fibers.
• These bundles are then cross-linked by NMMII to form stress fibers.
• Stress fibers are usually composed of 10-30 actin filaments.
• The contractility of stress fibers within the cell will therefore help to determine cellular morphogenesis.
• Stress fibers are primarily composed of actin and myosin.
• Rho induces the activity of actin stress fibers.
• However, it can interact with PDLIM1 / CLP-36 in the cytoplasm and localize to actin stress fibers.
• In addition, the inactivation of Rho protein by ADP-ribosylation in Rac1 microinjection reduced the formation of actin stress fibers.
• Because inhibition of RhoA results in a decrease in both stress fibers and focal adhesion, cell motility is increased.
• Transfection of p130 angiomotin into MAE cells results in change in cell shape, increased average cell size and stress fiber formation.
• The encoded protein may be a regulator of actin stress fibers in nonmuscle cells . [ provided by RefSeq, Jul 2008 ].
• As well, the dorsal stress fibers, transverse arcs and ventral stress fibers aid in the determination of cell morphology during cell migration.
• As well, the dorsal stress fibers, transverse arcs and ventral stress fibers aid in the determination of cell morphology during cell migration.
• The antiparallel arrangement of actin filaments within stress fibers is reinforced by ?-actinin, an actin filament crosslinking protein which contains antiparallel actin-binding domains.
• Yahara et al . ( 1982 ) found that higher concentrations ( 2-20 ?M ) of CD were needed to remove stress fibers.
• MTORC2 has been shown to function as an important regulator of the cytoskeleton through its stimulation of F-actin stress fibers, paxillin, PKC? ).
• It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis.
• In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction.